Karthik hails from a poor farmer's family in a village near Tirupati. He works at an IT company in Hyderabad. Chaitra is his colleague and tries her best to make him fall in love with her. But Karthik has a mission. He quits his high-salaried job and returns to his village with an aspiration to bring back the lost glory to the farmers and agriculture. The challenges he faces in convincing the villagers to return to agriculture and his inspirational success story as a farmer is what Sreekaram is all about.

Bharat, a graduate raised in London clueless about the future becomes the Chief Minister of Andhra Pradesh due to the circumstances. New to India and with no political knowledge he learns the ropes quickly and governs efficiently. However, while he endears himself to the crowd, he makes enemies out of the political class, including his own party members who create trouble for him and try to stop him from bringing in changes in the society.

A youngster tries to protect his sister-in-law, a transport official, from a dreaded goon who runs an illegal road transport business.

Subhash Patel, a retired army officer, takes on a group of drug traffickers. ACP Catherine, a corrupt lady officer, vows to find out the reason behind his mission.