Following the outbreak of a virus that wipes out the majority of the human population, a young woman documents her family's new life in quarantine and tries to protect her infected sister.

When Rango, a lost family pet, accidentally winds up in the gritty, gun-slinging town of Dirt, the less-than-courageous lizard suddenly finds he stands out. Welcomed as the last hope the town has been waiting for, new Sheriff Rango is forced to play his new role to the hilt.